Fragments are a significant subject of physical, mathematical, bioinformational, chemical (especially biochemical) and biological investigations. A lot of examples of fragments can be demonstrated in art also. We suggested the term “fragmentomics” for the science field studying the set of fragments and to call “fragmentome” the whole set of fragments.
The principles of fragmentomics were applied to the linear biomolecules such as proteins, in particular, food proteins. Until recently food proteins were considered to be an energy source and a source of amino acids required for protein synthesis only. However, food protein fragments can perform some regulatory functions. Theoretical justification of it was performed.
For this the primary structures of food protein fragments were compared with amino acid sequences of known natural regulatory oligopeptides in silico. Many of them were identified as enzyme inhibitors, regulators of nervous, endocrine, immune system, and others. It has been taken into account that fragments formed as a result of protein cleavage by proteolytic enzymes. It appeared that the lifetime of them before the cleavage in the gastrointestinal tract could be enough for performing corrective functions. Practical importance of these results is noted.


Short Biography of Alexander Zamyatnin

Prof., D.Sci. (biology), PhD (physics & mathematics) Alexander A. Zamyatnin (born in 1940) is a physicist (M.V.Lomonosov Moscow State University), associated investigator of Santa Maria Technical University (Center of biotechnology from 2006, Department of informatics from 2009). His area of expertise is endogenous oligopeptides (neuropeptides, hormones, toxins, antimicrobial), protein thermodynamics, structure-function relationship, ligand-receptor interaction, biosensors, computer biochemistry and biophysics, biological data bases, and drug design. He is an author of more than 200 scientific publications and participant of tens scientific meetings in more than 20 countries. Many years his free unique EROP-Moscow oligopeptide database is used by many scientists in Internet: http://erop.inbi.ras.ru. He is a member of the European Peptide Society (from 1995).

Fecha: 5 de JuLio

Lugar: F-106, UTFSM


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